产品货号：
Z19744
中文名称：
LIS1/PAFAH1B1抗体
英文名称：
Anti-LIS1/PAFAH1B1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-LIS1/PAFAH1B1 Antibody |
| 指标别名 | LIS 1;LIS1;LIS2;Lissencephaly 1 protein;MDCR;MDS;PAF AH 45kDa subunit;PAF AH alpha;PAFAH;PAFAH alpha;PAFAH1B1;PAFAHA |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,ICC,IF |
| 基因名称 | PAFAH1B1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | LIS1 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human LIS1.The immunogen is located within amino acids 340 - 390 of LIS1. |
| 计算分子量 | 47kDa |
| 成分 | LIS1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | LIS1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Lissencephaly is a severe brain developmental disease characterized by the mislocalization of cortical neurons,a smooth cerebral surface,mental retardation,and seizures.Classical lissencephaly is caused by sporadic mutations in the LIS1 gene.While LIS1 is known to act in a pathway deactivating the lipid messenger platelet-activating factor,LIS1 forms a complex with Nudel and 14-3-3epsilon which is then transported from neuronal cell bodies through the actions of DISC1 and KIF5A,a microtubule-dependent directed motor protein kinesin.Decreased expression of LIS1 blocked neural stem cell division,morphogenesis,and motility,suggesting that LIS1 plays an important role in neuronal cell proliferation and localization in the developing brain.At least two isoforms of LIS1 are known to exist. |
| Uniprot ID | P43034 |
| 基因名全称 | Platelet-activating factor acetylhydrolase,isoform Ib,subunit 1 (45kDa) |
| 蛋白名全称 | Platelet-activating factor acetylhydrolase,isoform Ib,subunit 1 (45kDa) |
| 推荐稀释比 | LIS1 antibody can be used for detection of LIS1 by Western blot at 0.5 ～ 1μg/mL.Antibody can also be used for immunocytochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunocytochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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